On a flight from Los Angeles to Paris, a mad scientist on the run from the CIA is transporting a coffin containing the body of a colleague infected with a genetically modified virus. While the 747 crosses a violent thunderstorm, the instability of the aircraft allows the corpse to get out of its container.

When the last evacuation flight out of war-torn Africa crashes off the coast, American Air Force Engineer Lieutenant Brian Murphy (ROB FREEMAN) emerges as the sole survivor in a land where the dead are returning to life and attacking the living.